Cytoplasmic iron is stored by ferritin heteropolymers, which consist of heavy (FtH) and light (FtL) chains that rise concomitantly in response to the presence of excessive iron ( Figures 4GI , and Supplementary Figures S3E, F )
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It has been reported that the low expression of NCOA4 in cells is accompanied by an increased Fe 2+ and oxidative stress level, a decreased GSH level
GRAS notice: Spirulina (Cyanotech Corporation) (2003)
Therefore, inhibiting GLS could effectively starve cancer cells of the glutamine essential to their survival and prevent further glutathione synthesis, thus increasing cancer cell exposure to excessive ROS levels [40]
